Retatrutide (Research Compound Only)

Retatrutide is a potent agonist at the human GCGR, GIPR, and GLP-1R in vitro.

It also showed potent triple agonism in vivo, with activity on all 3 receptors in mice.

reduced body weight and calorie intake in obese mice, and this effect was augmented by an increase in energy expenditure.

In a phase 1 study in healthy participants, LY3437943 was safe and tolerable, with a pharmacokinetic profile supporting once-weekly dosing.

LY3437943 also reduced body weight and improved metabolic health in obese mice in a dose-dependent manner.